RT Journal Article
SR Electronic
T1 Type 1 Adenylyl Cyclase Is Essential for Maintenance of Remote Contextual Fear Memory
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 12864
OP 12867
DO 10.1523/JNEUROSCI.2413-08.2008
VO 28
IS 48
A1 Qiang Shan
A1 Guy C.-K. Chan
A1 Daniel R. Storm
YR 2008
UL http://www.jneurosci.org/content/28/48/12864.abstract
AB Although molecular mechanisms for hippocampus-dependent memory have been extensively studied, much less is known about signaling events important for remote memory. Here we report that mice lacking type 1 adenylyl cyclase (AC1) are able to establish and retrieve remote contextual memory but unable to sustain it as long as wild-type mice. Interestingly, mice overexpressing AC1 show superior remote contextual memory even though they exhibit normal hippocampus-dependent contextual memory. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory.