PT  - JOURNAL ARTICLE
AU  - Laura-Adela Harsan
AU  - Jérôme Steibel
AU  - Anita Zaremba
AU  - Arnaud Agin
AU  - Rémy Sapin
AU  - Patrick Poulet
AU  - Blandine Guignard
AU  - Nathalie Parizel
AU  - Daniel Grucker
AU  - Nelly Boehm
AU  - Robert H. Miller
AU  - M. Said Ghandour
TI  - Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging
AID  - 10.1523/JNEUROSCI.4453-08.2008
DP  - 2008 Dec 24
TA  - The Journal of Neuroscience
PG  - 14189--14201
VI  - 28
IP  - 52
4099  - http://www.jneurosci.org/content/28/52/14189.short
4100  - http://www.jneurosci.org/content/28/52/14189.full
SO  - J. Neurosci.2008 Dec 24; 28
AB  - The failure of the remyelination processes in multiple sclerosis contributes to the formation of chronic demyelinated plaques that lead to severe neurological deficits. Long-term cuprizone treatment of C57BL/6 mice resulted in pronounced white matter pathology characterized by oligodendrocyte depletion, irreversible demyelination and persistent functional deficits after cuprizone withdrawal. The use of a combination of in vivo diffusion tensor magnetic resonance imaging (DT-MRI) and histological analyses allowed for an accurate longitudinal assessment of demyelination. Injection of triiodothyronine (T3) hormone over a 3 week interval after cuprizone withdrawal progressively restored the normal DT-MRI phenotype accompanied by an improvement of clinical signs and remyelination. The effects of T3 were not restricted to the later stages of remyelination but increased the expression of sonic hedgehog and the numbers of Olig2+ and PSA-NCAM+ precursors and proliferative cells. Our findings establish a role for T3 as an inducer of oligodendrocyte progenitor cells in adult mouse brain following chronic demyelination.