RT Journal Article
SR Electronic
T1 Neural Markers of Inhibition in Human Memory Retrieval
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 13419
OP 13427
DO 10.1523/JNEUROSCI.1916-08.2008
VO 28
IS 50
A1 Maria Wimber
A1 Karl-Heinz Bäuml
A1 Zara Bergström
A1 Gerasimos Markopoulos
A1 Hans-Jochen Heinze
A1 Alan Richardson-Klavehn
YR 2008
UL http://www.jneurosci.org/content/28/50/13419.abstract
AB Retrieving particular information from memory facilitates the later retrieval of that information, but also impairs the later retrieval of related, interfering information. It has been theorized that this retrieval-induced forgetting reflects inhibition of interfering memory representations. We used event-related fMRI to investigate the functional neuroanatomy of this impaired retrieval, at the time the impairment is observed. Neural activity differences between impaired and facilitated information occurred in left ventrolateral prefrontal cortex (VLPFC, BA 45 and 47), precuneus (BA 7), and right inferior parietal lobule (IPL, BA 40). Activity in left anterior VLPFC (BA 47) and left posterior temporal cortex (BA 22), regions implicated in the controlled retrieval of weak semantic memory representations, predicted the degree of retrieval-induced forgetting. In contrast, activity in precuneus and right IPL predicted the degree of retrieval-induced facilitation. Our findings demonstrate that impairment of interfering memories and facilitation of practiced memories involve distinct neural processes, and suggest that the impairment reflects inhibition that weakens interfering memory representations.