RT Journal Article
SR Electronic
T1 Immediate-Early Gene Expression at Rest Recapitulates Recent Experience
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 1030
OP 1033
DO 10.1523/JNEUROSCI.4235-07.2008
VO 28
IS 5
A1 Marrone, Diano F.
A1 Schaner, Michael J.
A1 McNaughton, Bruce L.
A1 Worley, Paul F.
A1 Barnes, Carol A.
YR 2008
UL http://www.jneurosci.org/content/28/5/1030.abstract
AB Immediate-early genes (IEGs) are tightly coupled to cellular activity and play a critical role in regulating synaptic plasticity. While encoding spatial experience, hippocampal principal cells express IEGs in a behaviorally dependent and cell-specific manner. This expression can be detected through the use of cellular compartment analysis of temporal activity by fluorescence in situ hybridization to generate estimates of cellular activity that match direct neuronal recording under comparable conditions. During rest, IEG expression continues to occur in a small number of cells, and the role of this basal expression is unknown. Imaging IEGs expressed during exploration and adjacent rest periods reveals that “constitutive” IEG expression during rest is not random. Rather, consistent with proposed memory consolidation mechanisms, it recapitulates a subset of the pattern generated by recent experience.