TY - JOUR T1 - Nuclei Accumbens Phase Synchrony Predicts Decision-Making Reversals Following Negative Feedback JF - The Journal of Neuroscience JO - J. Neurosci. SP - 7591 LP - 7598 DO - 10.1523/JNEUROSCI.5335-08.2009 VL - 29 IS - 23 AU - Michael X Cohen AU - Nikolai Axmacher AU - Doris Lenartz AU - Christian E. Elger AU - Volker Sturm AU - Thomas E. Schlaepfer Y1 - 2009/06/10 UR - http://www.jneurosci.org/content/29/23/7591.abstract N2 - The nucleus accumbens plays a key role in reinforcement-guided behaviors. Here, we report that electrophysiological oscillatory phase synchrony between the two nuclei accumbens may play a crucial role in using negative feedback to guide decision making. We recorded local field potentials from the human nucleus accumbens and the medial frontal cortex (via surface EEG) from patients who had deep brain stimulation electrodes implanted. Patients performed a reversal learning task in which they decided whether to alter their decision strategy following monetary losses. Strategy switches following losses were preceded by enhanced theta (4–8 Hz) phase synchrony between the nuclei accumbens, and a break-down of gamma (20–80 Hz)–α (8–12 Hz) coupling. Furthermore, the strength of the intersite phase synchrony predicted response time adjustments in the subsequent trial. These findings suggest that a neural network including the nucleus accumbens bilaterally becomes functionally connected via theta phase synchrony to signal the need to adjust behavior. ER -