TY - JOUR T1 - Nonlinear Phase–Phase Cross-Frequency Coupling Mediates Communication between Distant Sites in Human Neocortex JF - The Journal of Neuroscience JO - J. Neurosci. SP - 426 LP - 435 DO - 10.1523/JNEUROSCI.3688-08.2009 VL - 29 IS - 2 AU - Felix Darvas AU - Kai J. Miller AU - Rajesh P. N. Rao AU - Jeffrey G. Ojemann Y1 - 2009/01/14 UR - http://www.jneurosci.org/content/29/2/426.abstract N2 - Human cognition is thought to be mediated by large-scale interactions between distant sites in the neocortex. Synchronization between different cortical areas has been suggested as one possible mechanism for corticocortical interaction. Here, we report robust, directional cross-frequency synchronization between distant sensorimotor sites in human neocortex during a movement task. In four subjects, electrocorticographic recordings from the cortical surface revealed a low-frequency rhythm (10–13 Hz) that combined with a higher frequency (77–82 Hz) in a ventral region of the premotor cortex to produce a third rhythm at the sum of these two frequencies in a distant motor site. Such cross-frequency coupling implies a nonlinear interaction between these cortical sites. These findings demonstrate that task-specific, phase–phase coupling can support communication between distant areas of the human neocortex. ER -