RT Journal Article
SR Electronic
T1 Broadband Shifts in Local Field Potential Power Spectra Are Correlated with Single-Neuron Spiking in Humans
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 13613
OP 13620
DO 10.1523/JNEUROSCI.2041-09.2009
VO 29
IS 43
A1 Jeremy R. Manning
A1 Joshua Jacobs
A1 Itzhak Fried
A1 Michael J. Kahana
YR 2009
UL http://www.jneurosci.org/content/29/43/13613.abstract
AB A fundamental question in neuroscience concerns the relation between the spiking of individual neurons and the aggregate electrical activity of neuronal ensembles as seen in local field potentials (LFPs). Because LFPs reflect both spiking activity and subthreshold events, this question is not simply one of data aggregation. Recording from 20 neurosurgical patients, we directly examined the relation between LFPs and neuronal spiking. Examining 2030 neurons in widespread brain regions, we found that firing rates were positively correlated with broadband (2–150 Hz) shifts in the LFP power spectrum. In contrast, narrowband oscillations correlated both positively and negatively with firing rates at different recording sites. Broadband power shifts were a more reliable predictor of neuronal spiking than narrowband power shifts. These findings suggest that broadband LFP power provides valuable information concerning neuronal activity beyond that contained in narrowband oscillations.