PT  - JOURNAL ARTICLE
AU  - Conde, Cecilia
AU  - Arias, Cristina
AU  - Robin, Maria
AU  - Li, Aiqun
AU  - Saito, Masaki
AU  - Chuang, Jen-Zen
AU  - Nairn, Angus C.
AU  - Sung, Ching-Hwa
AU  - Cáceres, Alfredo
TI  - Evidence for the Involvement of Lfc and Tctex-1 in Axon Formation
AID  - 10.1523/JNEUROSCI.5420-09.2010
DP  - 2010 May 12
TA  - The Journal of Neuroscience
PG  - 6793--6800
VI  - 30
IP  - 19
4099  - http://www.jneurosci.org/content/30/19/6793.short
4100  - http://www.jneurosci.org/content/30/19/6793.full
SO  - J. Neurosci.2010 May 12; 30
AB  - RhoA and Rac play key and opposite roles during neuronal polarization. We now show that Lfc, a guanosine nucleotide exchange factor (GEF), localizes to the Golgi apparatus and growth cones of developing neurons and negatively regulates neurite sprouting and axon formation through a Rho signaling pathway. Tctex-1, a dynein light chain implicated in axon outgrowth by modulating actin dynamics and Rac activity, colocalizes and physically interacts with Lfc, thus inhibiting its GEF activity, decreasing Rho-GTP levels, and functionally antagonizing Lfc during neurite formation.