RT Journal Article
SR Electronic
T1 Evidence for the Involvement of Lfc and Tctex-1 in Axon Formation
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 6793
OP 6800
DO 10.1523/JNEUROSCI.5420-09.2010
VO 30
IS 19
A1 Conde, Cecilia
A1 Arias, Cristina
A1 Robin, Maria
A1 Li, Aiqun
A1 Saito, Masaki
A1 Chuang, Jen-Zen
A1 Nairn, Angus C.
A1 Sung, Ching-Hwa
A1 Cáceres, Alfredo
YR 2010
UL http://www.jneurosci.org/content/30/19/6793.abstract
AB RhoA and Rac play key and opposite roles during neuronal polarization. We now show that Lfc, a guanosine nucleotide exchange factor (GEF), localizes to the Golgi apparatus and growth cones of developing neurons and negatively regulates neurite sprouting and axon formation through a Rho signaling pathway. Tctex-1, a dynein light chain implicated in axon outgrowth by modulating actin dynamics and Rac activity, colocalizes and physically interacts with Lfc, thus inhibiting its GEF activity, decreasing Rho-GTP levels, and functionally antagonizing Lfc during neurite formation.