RT Journal Article
SR Electronic
T1 MicroRNAs Are Essential for the Developmental Switch from Neurogenesis to Gliogenesis in the Developing Spinal Cord
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 8245
OP 8250
DO 10.1523/JNEUROSCI.1169-10.2010
VO 30
IS 24
A1 Kang Zheng
A1 Hong Li
A1 Ying Zhu
A1 Qiang Zhu
A1 Mengsheng Qiu
YR 2010
UL http://www.jneurosci.org/content/30/24/8245.abstract
AB In the developing CNS, neurons and glia are sequentially produced from the ventricular neural progenitor cells. One fundamental question in developmental neurobiology is what signals or factors control the developmental switch from neurogenesis to gliogenesis. Here we report that microRNAs (miRNAs) play an essential role in this important developmental process. Inhibition of miRNA formation in Olig1Cre-mediated Dicer conditional knock-out mice disrupted both oligodendrogenesis and astrogliogenesis in the ventral neuroepithelial cells. By contrast, the early patterning and development of motor neurons were not affected in the mutant spinal cord tissue.