PT  - JOURNAL ARTICLE
AU  - Xavier Caubit
AU  - Muriel Thoby-Brisson
AU  - Nicolas Voituron
AU  - Pierre Filippi
AU  - Michelle Bévengut
AU  - Hervé Faralli
AU  - Sébastien Zanella
AU  - Gilles Fortin
AU  - Gérard Hilaire
AU  - Laurent Fasano
TI  - <em>Teashirt 3</em> Regulates Development of Neurons Involved in Both Respiratory Rhythm and Airflow Control
AID  - 10.1523/JNEUROSCI.1765-10.2010
DP  - 2010 Jul 14
TA  - The Journal of Neuroscience
PG  - 9465--9476
VI  - 30
IP  - 28
4099  - http://www.jneurosci.org/content/30/28/9465.short
4100  - http://www.jneurosci.org/content/30/28/9465.full
SO  - J. Neurosci.2010 Jul 14; 30
AB  - Neonatal breathing in mammals involves multiple neuronal circuits, but its genetic basis remains unclear. Mice deficient for the zinc finger protein Teashirt 3 (TSHZ3) fail to breathe and die at birth. Tshz3 is expressed in multiple areas of the brainstem involved in respiration, including the pre-Bötzinger complex (preBötC), the embryonic parafacial respiratory group (e-pF), and cranial motoneurons that control the upper airways. Tshz3 inactivation led to pronounced cell death of motoneurons in the nucleus ambiguus and induced strong alterations of rhythmogenesis in the e-pF oscillator. In contrast, the preBötC oscillator appeared to be unaffected. These deficits result in impaired upper airway function, abnormal central respiratory rhythm generation, and altered responses to pH changes. Thus, a single gene, Tshz3, controls the development of diverse components of the circuitry required for breathing.