RT Journal Article
SR Electronic
T1 <em>Teashirt 3</em> Regulates Development of Neurons Involved in Both Respiratory Rhythm and Airflow Control
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9465
OP 9476
DO 10.1523/JNEUROSCI.1765-10.2010
VO 30
IS 28
A1 Caubit, Xavier
A1 Thoby-Brisson, Muriel
A1 Voituron, Nicolas
A1 Filippi, Pierre
A1 Bévengut, Michelle
A1 Faralli, Hervé
A1 Zanella, Sébastien
A1 Fortin, Gilles
A1 Hilaire, Gérard
A1 Fasano, Laurent
YR 2010
UL http://www.jneurosci.org/content/30/28/9465.abstract
AB Neonatal breathing in mammals involves multiple neuronal circuits, but its genetic basis remains unclear. Mice deficient for the zinc finger protein Teashirt 3 (TSHZ3) fail to breathe and die at birth. Tshz3 is expressed in multiple areas of the brainstem involved in respiration, including the pre-Bötzinger complex (preBötC), the embryonic parafacial respiratory group (e-pF), and cranial motoneurons that control the upper airways. Tshz3 inactivation led to pronounced cell death of motoneurons in the nucleus ambiguus and induced strong alterations of rhythmogenesis in the e-pF oscillator. In contrast, the preBötC oscillator appeared to be unaffected. These deficits result in impaired upper airway function, abnormal central respiratory rhythm generation, and altered responses to pH changes. Thus, a single gene, Tshz3, controls the development of diverse components of the circuitry required for breathing.