TY - JOUR T1 - Slow GABA Transient and Receptor Desensitization Shape Synaptic Responses Evoked by Hippocampal Neurogliaform Cells JF - The Journal of Neuroscience JO - J. Neurosci. SP - 9898 LP - 9909 DO - 10.1523/JNEUROSCI.5883-09.2010 VL - 30 IS - 29 AU - Theofanis Karayannis AU - David Elfant AU - Icnelia Huerta-Ocampo AU - Sundeep Teki AU - Ricardo S. Scott AU - Dmitri A. Rusakov AU - Mathew V. Jones AU - Marco Capogna Y1 - 2010/07/21 UR - http://www.jneurosci.org/content/30/29/9898.abstract N2 - The kinetics of GABAergic synaptic currents can vary by an order of magnitude depending on the cell type. The neurogliaform cell (NGFC) has recently been identified as a key generator of slow GABAA receptor-mediated volume transmission in the isocortex. However, the mechanisms underlying slow GABAA receptor-mediated IPSCs and their use-dependent plasticity remain unknown. Here, we provide experimental and modeling data showing that hippocampal NGFCs generate an unusually prolonged (tens of milliseconds) but low-concentration (micromolar range) GABA transient, which is responsible for the slow response kinetics and which leads to a robust desensitization of postsynaptic GABAA receptors. This strongly contributes to the use-dependent synaptic depression elicited by various patterns of NGFC activity including the one detected during theta network oscillations in vivo. Synaptic depression mediated by NGFCs is likely to play an important modulatory role in the feedforward inhibition of CA1 pyramidal cells provided by the entorhinal cortex. ER -