RT Journal Article
SR Electronic
T1 Slow GABA Transient and Receptor Desensitization Shape Synaptic Responses Evoked by Hippocampal Neurogliaform Cells
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9898
OP 9909
DO 10.1523/JNEUROSCI.5883-09.2010
VO 30
IS 29
A1 Karayannis, Theofanis
A1 Elfant, David
A1 Huerta-Ocampo, Icnelia
A1 Teki, Sundeep
A1 Scott, Ricardo S.
A1 Rusakov, Dmitri A.
A1 Jones, Mathew V.
A1 Capogna, Marco
YR 2010
UL http://www.jneurosci.org/content/30/29/9898.abstract
AB The kinetics of GABAergic synaptic currents can vary by an order of magnitude depending on the cell type. The neurogliaform cell (NGFC) has recently been identified as a key generator of slow GABAA receptor-mediated volume transmission in the isocortex. However, the mechanisms underlying slow GABAA receptor-mediated IPSCs and their use-dependent plasticity remain unknown. Here, we provide experimental and modeling data showing that hippocampal NGFCs generate an unusually prolonged (tens of milliseconds) but low-concentration (micromolar range) GABA transient, which is responsible for the slow response kinetics and which leads to a robust desensitization of postsynaptic GABAA receptors. This strongly contributes to the use-dependent synaptic depression elicited by various patterns of NGFC activity including the one detected during theta network oscillations in vivo. Synaptic depression mediated by NGFCs is likely to play an important modulatory role in the feedforward inhibition of CA1 pyramidal cells provided by the entorhinal cortex.