RT Journal Article
SR Electronic
T1 Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 14346
OP 14355
DO 10.1523/JNEUROSCI.3323-10.2010
VO 30
IS 43
A1 Paul C. Fletcher
A1 Antonella Napolitano
A1 Andrew Skeggs
A1 Sam R. Miller
A1 Bruno Delafont
A1 Victoria C. Cambridge
A1 Sanne de Wit
A1 Pradeep J. Nathan
A1 Allison Brooke
A1 Stephen O'Rahilly
A1 I. Sadaf Farooqi
A1 Edward T. Bullmore
YR 2010
UL http://www.jneurosci.org/content/30/43/14346.abstract
AB We used functional magnetic resonance imaging to explore brain responses to food images in overweight humans, examining independently the impact of a prescan meal (“satiety”) and the anti-obesity drug sibutramine, a serotonin and noradrenaline reuptake inhibitor. We identified significantly different responses to these manipulations in amygdala, hypothalamus, and ventral striatum. Each region was specifically responsive to high-calorie compared to low-calorie food images. However, the ventral striatal response was attenuated by satiety (but unaffected by sibutramine), while the hypothalamic and amygdala responses were attenuated by drug but unaffected by satiety. Direct assessment of regional interactions confirmed the significance of this double dissociation. We explored the regional responses in greater detail by determining whether they were predictive of eating behavior and weight change. We observed that across the different regions, the individual-specific magnitude of drug- and satiety-induced modulation was associated with both variables: the sibutramine-induced modulation of the hypothalamic response was correlated with the drug's impact on both weight and subsequently measured ad libitum eating. The satiety-induced modulation of striatal response also correlated with subsequent ad libitum eating. These results suggest that hypothalamus and amygdala have roles in the control of food intake that are distinct from those of ventral striatum. Furthermore, they support a regionally specific effect on brain function through which sibutramine exerts its clinical effect.