RT Journal Article
SR Electronic
T1 Synaptic Localization and Activity of ADAM10 Regulate Excitatory Synapses through N-Cadherin Cleavage
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 16343
OP 16355
DO 10.1523/JNEUROSCI.1984-10.2010
VO 30
IS 48
A1 Matteo Malinverno
A1 Mario Carta
A1 Roberta Epis
A1 Elena Marcello
A1 Chiara Verpelli
A1 Flaminio Cattabeni
A1 Carlo Sala
A1 Christophe Mulle
A1 Monica Di Luca
A1 Fabrizio Gardoni
YR 2010
UL http://www.jneurosci.org/content/30/48/16343.abstract
AB N-Cadherin has an important role during dendrite arborization, axon guidance, and synaptogenesis. In particular, at synaptic sites, N-cadherin is involved in the regulation of cell–cell adhesion and in morphology and plasticity control. Recent studies have shown that N-cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that impairing ADAM10 localization and activity at synaptic sites decreases its processing of N-cadherin. This leads to an accumulation of the full-length form of N-cadherin, to an increase in spine head width, and to modifications of the number and function of glutamate receptors of AMPA type, both in vitro and in vivo. Our results indicate a key role for ADAM10 in the complex sequence of events through which N-cadherin affects spine maturation and controls structure and function of glutamatergic synapses.