PT  - JOURNAL ARTICLE
AU  - Yanhong Shi
AU  - Xinyu Zhao
AU  - Jenny Hsieh
AU  - Hynek Wichterle
AU  - Soren Impey
AU  - Sourav Banerjee
AU  - Pierre Neveu
AU  - Kenneth S. Kosik
TI  - MicroRNA Regulation of Neural Stem Cells and Neurogenesis
AID  - 10.1523/JNEUROSCI.4280-10.2010
DP  - 2010 Nov 10
TA  - The Journal of Neuroscience
PG  - 14931--14936
VI  - 30
IP  - 45
4099  - http://www.jneurosci.org/content/30/45/14931.short
4100  - http://www.jneurosci.org/content/30/45/14931.full
SO  - J. Neurosci.2010 Nov 10; 30
AB  - MicroRNAs are a class of small RNA regulators that are involved in numerous cellular processes, including development, proliferation, differentiation, and plasticity. The emerging concept is that microRNAs play a central role in controlling the balance between stem cell self-renewal and fate determination by regulating the expression of stem cell regulators. This review will highlight recent advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs. It will cover microRNA functions during the entire process of neurogenesis, from neural stem cell self-renewal and fate determination to neuronal maturation, synaptic formation, and plasticity. The interplay between microRNAs and both cell-intrinsic and -extrinsic stem cell players, including transcription factors, epigenetic regulators, and extrinsic signaling molecules will be discussed. This is a summary of the topics covered in the mini-symposium on microRNA regulation of neural stem cells and neurogenesis in SFN 2010 and is not meant to be a comprehensive review of the subject.