TY - JOUR T1 - Growing Together and Growing Apart: Regional and Sex Differences in the Lifespan Developmental Trajectories of Functional Homotopy JF - The Journal of Neuroscience JO - J. Neurosci. SP - 15034 LP - 15043 DO - 10.1523/JNEUROSCI.2612-10.2010 VL - 30 IS - 45 AU - Xi-Nian Zuo AU - Clare Kelly AU - Adriana Di Martino AU - Maarten Mennes AU - Daniel S. Margulies AU - Saroja Bangaru AU - Rebecca Grzadzinski AU - Alan C. Evans AU - Yu-Feng Zang AU - F. Xavier Castellanos AU - Michael P. Milham Y1 - 2010/11/10 UR - http://www.jneurosci.org/content/30/45/15034.abstract N2 - Functional homotopy, the high degree of synchrony in spontaneous activity between geometrically corresponding interhemispheric (i.e., homotopic) regions, is a fundamental characteristic of the intrinsic functional architecture of the brain. However, despite its prominence, the lifespan development of the homotopic resting-state functional connectivity (RSFC) of the human brain is rarely directly examined in functional magnetic resonance imaging studies. Here, we systematically investigated age-related changes in homotopic RSFC in 214 healthy individuals ranging in age from 7 to 85 years. We observed marked age-related changes in homotopic RSFC with regionally specific developmental trajectories of varying levels of complexity. Sensorimotor regions tended to show increasing homotopic RSFC, whereas higher-order processing regions showed decreasing connectivity (i.e., increasing segregation) with age. More complex maturational curves were also detected, with regions such as the insula and lingual gyrus exhibiting quadratic trajectories and the superior frontal gyrus and putamen exhibiting cubic trajectories. Sex-related differences in the developmental trajectory of functional homotopy were detected within dorsolateral prefrontal cortex (Brodmann areas 9 and 46) and amygdala. Evidence of robust developmental effects in homotopic RSFC across the lifespan should serve to motivate studies of the physiological mechanisms underlying functional homotopy in neurodegenerative and psychiatric disorders. ER -