TY - JOUR T1 - Contribution of Dopamine D1 and D2 Receptors to Amygdala Activity in Human JF - The Journal of Neuroscience JO - J. Neurosci. SP - 3043 LP - 3047 DO - 10.1523/JNEUROSCI.5689-09.2010 VL - 30 IS - 8 AU - Hidehiko Takahashi AU - Harumasa Takano AU - Fumitoshi Kodaka AU - Ryosuke Arakawa AU - Makiko Yamada AU - Tatsui Otsuka AU - Yoshiyuki Hirano AU - Hideyuki Kikyo AU - Yoshiro Okubo AU - Motoichiro Kato AU - Takayuki Obata AU - Hiroshi Ito AU - Tetsuya Suhara Y1 - 2010/02/24 UR - http://www.jneurosci.org/content/30/8/3043.abstract N2 - Several animal studies have demonstrated functional roles of dopamine (DA) D1 and D2 receptors in amygdala activity. However, the contribution of DA D1 and D2 receptors to amygdala response induced by affective stimuli in human is unknown. To investigate the contribution of DA receptor subtypes to amygdala reactivity in human, we conducted a multimodal in vivo neuroimaging study in which DA D1 and D2 receptor bindings in the amygdala were measured with positron emission tomography (PET), and amygdala response induced by fearful faces was assessed by functional magnetic resonance imaging (fMRI) in healthy volunteers. We used multimodality voxelwise correlation analysis between fMRI signal and DA receptor binding measured by PET. DA D1 binding in the amygdala was positively correlated with amygdala signal change in response to fearful faces, but DA D2 binding in the amygdala was not related to amygdala signal change. DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective. ER -