RT Journal Article
SR Electronic
T1 Error Effects in Anterior Cingulate Cortex Reverse when Error Likelihood Is High
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 3467
OP 3472
DO 10.1523/JNEUROSCI.4130-09.2010
VO 30
IS 9
A1 Ryan K. Jessup
A1 Jerome R. Busemeyer
A1 Joshua W. Brown
YR 2010
UL http://www.jneurosci.org/content/30/9/3467.abstract
AB Strong error-related activity in medial prefrontal cortex (mPFC) has been shown repeatedly with neuroimaging and event-related potential studies for the last several decades. Multiple theories have been proposed to account for error effects, including comparator models and conflict detection models, but the neural mechanisms that generate error signals remain in dispute. Typical studies use relatively low error rates, confounding the expectedness and the desirability of an error. Here we show with a gambling task and functional magnetic resonance imaging that when losses are more frequent than wins, the mPFC error effect disappears, and moreover, exhibits the opposite pattern by responding more strongly to unexpected wins than losses. These findings provide perspective on recent ERP studies and suggest that mPFC error effects result from a comparison between actual and expected outcomes.