TY - JOUR T1 - Active Expiration Induced by Excitation of Ventral Medulla in Adult Anesthetized Rats JF - The Journal of Neuroscience JO - J. Neurosci. SP - 2895 LP - 2905 DO - 10.1523/JNEUROSCI.5338-10.2011 VL - 31 IS - 8 AU - Silvia Pagliardini AU - Wiktor A. Janczewski AU - Wenbin Tan AU - Clayton T. Dickson AU - Karl Deisseroth AU - Jack L. Feldman Y1 - 2011/02/23 UR - http://www.jneurosci.org/content/31/8/2895.abstract N2 - Data from perinatal and juvenile rodents support our hypothesis that the preBötzinger complex generates inspiratory rhythm and the retrotrapezoid nucleus–parafacial respiratory group (RTN/pFRG) generates active expiration (AE). Although the role of the RTN/pFRG in adulthood is disputed, we hypothesized that its rhythmogenicity persists but is typically silenced by synaptic inhibition. We show in adult anesthetized rats that local pharmacological disinhibition or optogenetic excitation of the RTN/pFRG can generate AE and transforms previously silent RTN/pFRG neurons into rhythmically active cells whose firing is correlated with late-phase active expiration. Brief excitatory stimuli also reset the respiratory rhythm, indicating strong coupling of AE to inspiration. The AE network location in adult rats overlaps with the perinatal pFRG and appears lateral to the chemosensitive region of adult RTN. We suggest that (1) the RTN/pFRG contains a conditional oscillator that generates AE, and (2) at rest and in anesthesia, synaptic inhibition of RTN/pFRG suppresses AE. ER -