RT Journal Article
SR Electronic
T1 Bruchpilot, A Synaptic Active Zone Protein for Anesthesia-Resistant Memory
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 3453
OP 3458
DO 10.1523/JNEUROSCI.2585-10.2011
VO 31
IS 9
A1 Knapek, Stephan
A1 Sigrist, Stephan
A1 Tanimoto, Hiromu
YR 2011
UL http://www.jneurosci.org/content/31/9/3453.abstract
AB In Drosophila, aversive associative memory of an odor consists of heterogeneous components with different stabilities. Here we report that Bruchpilot (Brp), a ubiquitous presynaptic active zone protein, is required for olfactory memory. Brp was shown before to facilitate efficient vesicle release, particularly at low stimulation frequencies. Transgenic knockdown in the Kenyon cells of the mushroom body, the second-order olfactory interneurons, revealed that Brp is required for olfactory memory. We further demonstrate that Brp in the Kenyon cells preferentially functions for anesthesia-resistant memory. Another presynaptic protein, Synapsin, was shown previously to be required selectively for the labile anesthesia-sensitive memory, which is less affected in brp knockdown. Thus, consolidated and labile components of aversive olfactory memory can be dissociated by the function of different presynaptic proteins.