RT Journal Article
SR Electronic
T1 The distribution and morphology of opioid peptide immunoreactive neurons in the cerebral cortex of rats
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 1104
OP 1117
DO 10.1523/JNEUROSCI.04-04-01104.1984
VO 4
IS 4
A1 JF McGinty
A1 D van der Kooy
A1 FE Bloom
YR 1984
UL http://www.jneurosci.org/content/4/4/1104.abstract
AB Pharmacological and biochemical evidence has implied that a widespread opioid peptide system exists within the cerebral cortex to mediate a variety of opiate effects. However, immunocytochemical detection of opioid peptides in the cortex has been limited. Using antisera to enkephalin and bovine adrenal medullary peptide, both fragments of proenkephalin, and an antiserum to dynorphin A, a fragment of prodynorphin, we now describe the regional and laminar distribution of a widespread population of olfactory cortical and neocortical cell bodies and fibers with opioid immunoreactivity in rats. Neurons stained with each antiserum are distributed bimodally in layers II and III and V and VI of neocortex as well as in layers II and III of olfactory cortex. The widespread distribution and heterogeneous morphology of cortical cells containing proenkephalin and dynorphin-A immunoreactivity suggest that opioid peptide-containing neurons may influence the functioning of local, commissural, and projection neurons in rat cerebral cortex.