PT  - JOURNAL ARTICLE
AU  - Rayport, SG
AU  - Schacher, S
TI  - Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization
AID  - 10.1523/JNEUROSCI.06-03-00759.1986
DP  - 1986 Mar 01
TA  - The Journal of Neuroscience
PG  - 759--763
VI  - 6
IP  - 3
4099  - http://www.jneurosci.org/content/6/3/759.short
4100  - http://www.jneurosci.org/content/6/3/759.full
SO  - J. Neurosci.1986 Mar 01; 6
AB  - The gill withdrawal reflex of the marine mollusk, Aplysia californica, shows habituation and sensitization, two simple forms of learning. In order to extend the cellular studies on synaptic plasticity underlying the changes in the reflex behavior, and to explore further the development of synaptic plasticity during synapse formation, we have sought to establish the neural circuit of the gill withdrawal reflex in vitro. We report here the reconstruction of the elementary gill withdrawal circuit in cell culture and find that the cells show short- term homosynaptic depression and heterosynaptic facilitation, the cellular mechanisms of habituation and sensitization, respectively.