PT  - JOURNAL ARTICLE
AU  - Kapfhammer, JP
AU  - Raper, JA
TI  - Collapse of growth cone structure on contact with specific neurites in culture
AID  - 10.1523/JNEUROSCI.07-01-00201.1987
DP  - 1987 Jan 01
TA  - The Journal of Neuroscience
PG  - 201--212
VI  - 7
IP  - 1
4099  - http://www.jneurosci.org/content/7/1/201.short
4100  - http://www.jneurosci.org/content/7/1/201.full
SO  - J. Neurosci.1987 Jan 01; 7
AB  - We have studied the morphology of embryonic chick retinal and sympathetic growth cones as they meet retinal and sympathetic neurites grown in culture. Growth cones preserve their normal morphology and ability to locomote when retinal growth cones contact retinal neurites or when sympathetic growth cones contact sympathetic neurites. Growth cones collapse and their motility ceases when retinal growth cones contact sympathetic neurites or when sympathetic growth cones contact retinal neurites. Collapse was never observed before a growth cone touched a neurite. As a growth cone collapses, the neurite it leads retracts. After a brief pause, a new growth cone is organized and extension recommences. These results suggest that contact-mediated inhibition of locomotion could play a role in growth cone guidance.