PT  - JOURNAL ARTICLE
AU  - Fox, PT
AU  - Miezin, FM
AU  - Allman, JM
AU  - Van Essen, DC
AU  - Raichle, ME
TI  - Retinotopic organization of human visual cortex mapped with positron- emission tomography
AID  - 10.1523/JNEUROSCI.07-03-00913.1987
DP  - 1987 Mar 01
TA  - The Journal of Neuroscience
PG  - 913--922
VI  - 7
IP  - 3
4099  - http://www.jneurosci.org/content/7/3/913.short
4100  - http://www.jneurosci.org/content/7/3/913.full
SO  - J. Neurosci.1987 Mar 01; 7
AB  - The retinotopic organization of primary visual cortex was mapped in normal human volunteers. Positron-emission tomographic measurements of regional cerebral blood flow were employed to detect focal functional brain activation. Oxygen-15-labeled water, delivered by intravenous bolus, was used as the blood flow tracer to allow multiple stimulated- state (n = 5) and control-state (n = 3) measurements to be acquired for each of 7 subjects. Responses were identified by applying a maximum- detection algorithm to subtraction-format images of the stimulus- induced change in cerebral blood flow. Response locales were described using a standardized system of stereotactic coordinates. Changes in stimulus location (macular, perimacular, peripheral, upper-field, lower- field) caused systematic, highly significant changes in response locale within visual cortex. Discrete extrastriate visual responses were also observed.