PT - JOURNAL ARTICLE AU - Giulian, D AU - Woodward, J AU - Young, DG AU - Krebs, JF AU - Lachman, LB TI - Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization AID - 10.1523/JNEUROSCI.08-07-02485.1988 DP - 1988 Jul 01 TA - The Journal of Neuroscience PG - 2485--2490 VI - 8 IP - 7 4099 - http://www.jneurosci.org/content/8/7/2485.short 4100 - http://www.jneurosci.org/content/8/7/2485.full SO - J. Neurosci.1988 Jul 01; 8 AB - Interleukin-1 (IL-1), a protein produced by mononuclear phagocytes, helps to initiate the inflammatory response through its action upon a diverse population of cells. Recently this immunomodulator has been detected at sites of traumatized brain. As reported here, recombinant forms of IL-1 injected into the cerebral cortex of adult rats elicit not only astrogliosis but also new blood vessel growth. These responses are typical of brain injury and suggest that IL-1-secreting inflammatory cells may mediate wound healing in the CNS.