RT Journal Article
SR Electronic
T1 Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 2485
OP 2490
DO 10.1523/JNEUROSCI.08-07-02485.1988
VO 8
IS 7
A1 Giulian, D
A1 Woodward, J
A1 Young, DG
A1 Krebs, JF
A1 Lachman, LB
YR 1988
UL http://www.jneurosci.org/content/8/7/2485.abstract
AB Interleukin-1 (IL-1), a protein produced by mononuclear phagocytes, helps to initiate the inflammatory response through its action upon a diverse population of cells. Recently this immunomodulator has been detected at sites of traumatized brain. As reported here, recombinant forms of IL-1 injected into the cerebral cortex of adult rats elicit not only astrogliosis but also new blood vessel growth. These responses are typical of brain injury and suggest that IL-1-secreting inflammatory cells may mediate wound healing in the CNS.