PT  - JOURNAL ARTICLE
AU  - Jackson, CA
AU  - Peduzzi, JD
AU  - Hickey, TL
TI  - Visual cortex development in the ferret. I. Genesis and migration of visual cortical neurons
AID  - 10.1523/JNEUROSCI.09-04-01242.1989
DP  - 1989 Apr 01
TA  - The Journal of Neuroscience
PG  - 1242--1253
VI  - 9
IP  - 4
4099  - http://www.jneurosci.org/content/9/4/1242.short
4100  - http://www.jneurosci.org/content/9/4/1242.full
SO  - J. Neurosci.1989 Apr 01; 9
AB  - The production of ferret visual cortical neurons was studied using 3H- thymidine autoradiography. The genesis of cortical neurons begins on or slightly before embryonic day 20 (E20) of the 41 d gestational period, continues postnatally until 2 weeks after birth (P14), and follows an inside-out radial gradient with neurons for the deeper cortical layers being generated before those for the superficial layers. Layer I neurons are generated both early (E20-E30) and late (P1-P14) in the period of cortical neurogenesis and, thus, provide at least a partial exception to the inside-out gradient of cortical neurogenesis. Tangential gradients of cortical neurogenesis extend across areas 17 and 18 in both the anterior-to-posterior and lateral-to-medial directions. Neither of these gradients bears a meaningful relationship to the cortical representation of the visual field. Most infragranular and granular layer neurons are generated prenatally, while most supragranular layer neurons are produced postnatally. Neurons destined for a given layer are produced over a period of several days, and the neurons generated on any given day contribute to the formation of 2 or more cortical layers. In general, prenatally generated neurons complete their migration in 1 week or less, while most postnatally generated neurons require approximately 2 weeks to complete their migration.