TY - JOUR T1 - Vulnerability to Depression: From Brain Neuroplasticity to Identification of Biomarkers JF - The Journal of Neuroscience JO - J. Neurosci. SP - 12889 LP - 12899 DO - 10.1523/JNEUROSCI.1309-11.2011 VL - 31 IS - 36 AU - Aurélie Blugeot AU - Cyril Rivat AU - Elodie Bouvier AU - Jenny Molet AU - Amandine Mouchard AU - Brigitte Zeau AU - Christophe Bernard AU - Jean-Jacques Benoliel AU - Chrystel Becker Y1 - 2011/09/07 UR - http://www.jneurosci.org/content/31/36/12889.abstract N2 - A stressful event increases the risk of developing depression later in life, but the possible predisposing factors remain unknown. Our study aims to characterize latent vulnerability traits underlying the development of depressive disorders in adult animals. Four weeks after a priming stressful event, serum corticosterone concentration returned to control values in all animals, whereas the other biological parameters returned to basal level in only 58% of animals (called nonvulnerable). In contrast, 42% of animals displayed persistent decreased serum and hippocampus BDNF concentrations, reduced hippocampal volume and neurogenesis, CA3 dendritic retraction and decrease in spine density, as well as amygdala neuron hypertrophy, constituting latent vulnerability traits to depression. In this group, called vulnerable, a subsequent mild stress evoked a rise of serum corticosterone levels and a “depressive” phenotype, in contrast to nonvulnerable animals. Intracerebroventricular administration of 7,8-dihydroxyflavone, a selective TrkB receptor agonist, dampened the development of the “depressive” phenotype. Our results thus characterize the presence of latent vulnerability traits that underlie the emergence of depression and identify the association of low BDNF with normal corticosterone serum concentrations as a predictive biomarker of vulnerability to depression. ER -