RT Journal Article
SR Electronic
T1 FXR1P But Not FMRP Regulates the Levels of Mammalian Brain-Specific microRNA-9 and microRNA-124
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 13705
OP 13709
DO 10.1523/JNEUROSCI.2827-11.2011
VO 31
IS 39
A1 Xu, Xia-Lian
A1 Zong, Ruiting
A1 Li, Zhaodong
A1 Biswas, Md Helal Uddin
A1 Fang, Zhe
A1 Nelson, David L.
A1 Gao, Fen-Biao
YR 2011
UL http://www.jneurosci.org/content/31/39/13705.abstract
AB Mammalian brain-specific miR-9 and miR-124 have been implicated in several aspects of neuronal development and function. However, it is not known how their expression levels are regulated in vivo. We found that the levels of miR-9 and miR-124 are regulated by FXR1P but not by the loss of FXR2P or FMRP in vivo, a mouse model of fragile X syndrome. Surprisingly, the levels of miR-9 and miR-124 are elevated in fmr1/fxr2 double-knock-out mice, in part reflecting posttranscriptional upregulation of FXR1P. Indeed, FXR1P is required for efficient processing of pre-miR-9 and pre-miR-124 in vitro and forms a complex with Dicer and pre-miRNAs. These findings reveal differential roles of FMRP family proteins in controlling the expression levels of brain-specific miRNAs.