RT Journal Article
SR Electronic
T1 The Neurophysiology and Pathology of Brain Zinc
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 16076
OP 16085
DO 10.1523/JNEUROSCI.3454-11.2011
VO 31
IS 45
A1 Sensi, Stefano L.
A1 Paoletti, Pierre
A1 Koh, Jae-Young
A1 Aizenman, Elias
A1 Bush, Ashley I.
A1 Hershfinkel, Michal
YR 2011
UL http://www.jneurosci.org/content/31/45/16076.abstract
AB Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability of genetically modified animal models, selective zinc-sensitive fluorescent probes, and novel chelators is producing a remarkable body of exciting new data that clearly establishes this metal ion as a key modulator of intracellular and intercellular neuronal signaling. In this Mini-Symposium, we will review and discuss the most recent findings that link zinc to synaptic function as well as the injurious effects of zinc dyshomeostasis within the context of neuronal death associated with major human neurological disorders, including stroke, epilepsy, and Alzheimer's disease.