RT Journal Article
SR Electronic
T1 Short- and Long-Term Plasticity at the Axon Initial Segment
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 16049
OP 16055
DO 10.1523/JNEUROSCI.4064-11.2011
VO 31
IS 45
A1 Grubb, Matthew S.
A1 Shu, Yousheng
A1 Kuba, Hiroshi
A1 Rasband, Matthew N.
A1 Wimmer, Verena C.
A1 Bender, Kevin J.
YR 2011
UL http://www.jneurosci.org/content/31/45/16049.abstract
AB The axon initial segment (AIS) is a highly specialized neuronal subregion that is the site of action potential initiation and the boundary between axonal and somatodendritic compartments. In recent years, our understanding of the molecular structure of the AIS, its maturation, and its multiple fundamental roles in neuronal function has seen major advances. We are beginning to appreciate that the AIS is dynamically regulated, both over short timescales via adaptations in ion channel function, and long timescales via activity-dependent structural reorganization. Here, we review results from this emerging field highlighting how structural and functional plasticity relate to the development of the initial segment, and to neuronal disorders linked to AIS dysfunction.