RT Journal Article SR Electronic T1 Amping Up Effort: Effects of d-Amphetamine on Human Effort-Based Decision-Making JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 16597 OP 16602 DO 10.1523/JNEUROSCI.4387-11.2011 VO 31 IS 46 A1 Margaret C. Wardle A1 Michael T. Treadway A1 Leah M. Mayo A1 David H. Zald A1 Harriet de Wit YR 2011 UL http://www.jneurosci.org/content/31/46/16597.abstract AB Animal studies suggest the neurotransmitter dopamine (DA) plays an important role in decision-making. In rats, DA depletion decreases tolerance for effort and probability costs, while drugs enhancing DA increase tolerance for these costs. However, data regarding the effect of DA manipulations on effort and probability costs in humans remain scarce. The current study examined acute effects of d-amphetamine, an indirect DA agonist, on willingness of healthy human volunteers to exert effort for monetary rewards at varying levels of reward value and reward probability. Based on preclinical research, we predicted amphetamine would increase exertion of effort, particularly when reward probability was low. Over three sessions, 17 healthy normal adults received placebo, d-amphetamine 10 mg, and 20 mg under counterbalanced double-blind conditions and completed the Effort Expenditure for Rewards Task. Consistent with predictions, amphetamine enhanced willingness to exert effort, particularly when reward probability was lower. Amphetamine did not alter effects of reward magnitude on willingness to exert effort. Amphetamine sped task performance, but its psychomotor effects were not strongly related to its effects on decision-making. This is the first demonstration in humans that dopaminergic manipulations alter willingness to exert effort for rewards. These findings help elucidate neurochemical substrates of choice, with implications for neuropsychiatric diseases characterized by dopaminergic dysfunction and motivational deficits.