TY - JOUR T1 - Multimodal Quantitative Magnetic Resonance Imaging of Thalamic Development and Aging across the Human Lifespan: Implications to Neurodegeneration in Multiple Sclerosis JF - The Journal of Neuroscience JO - J. Neurosci. SP - 16826 LP - 16832 DO - 10.1523/JNEUROSCI.4184-11.2011 VL - 31 IS - 46 AU - Khader M. Hasan AU - Indika S. Walimuni AU - Humaira Abid AU - Richard E. Frye AU - Linda Ewing-Cobbs AU - Jerry S. Wolinsky AU - Ponnada A. Narayana Y1 - 2011/11/16 UR - http://www.jneurosci.org/content/31/46/16826.abstract N2 - The human brain thalami play essential roles in integrating cognitive, sensory, and motor functions. In multiple sclerosis (MS), quantitative magnetic resonance imaging (qMRI) measurements of the thalami provide important biomarkers of disease progression, but late development and aging confound the interpretation of data collected from patients over a wide age range. Thalamic tissue volume loss due to natural aging and its interplay with lesion-driven pathology has not been investigated previously. In this work, we used standardized thalamic volumetry combined with diffusion tensor imaging, T2 relaxometry, and lesion mapping on large cohorts of controls (N = 255, age range = 6.2–69.1 years) and MS patients (N = 109, age range = 20.8–68.5 years) to demonstrate early age- and lesion-independent thalamic neurodegeneration. ER -