PT  - JOURNAL ARTICLE
AU  - Po-Han Chiang
AU  - Pu-Yeh Wu
AU  - Tzu-Wei Kuo
AU  - Yu-Chao Liu
AU  - Chu-Fang Chan
AU  - Ta-Chun Chien
AU  - Jen-Kun Cheng
AU  - Yu-Yin Huang
AU  - Cheng-Di Chiu
AU  - Cheng-Chang Lien
TI  - GABA Is Depolarizing in Hippocampal Dentate Granule Cells of the Adolescent and Adult Rats
AID  - 10.1523/JNEUROSCI.3393-11.2012
DP  - 2012 Jan 04
TA  - The Journal of Neuroscience
PG  - 62--67
VI  - 32
IP  - 1
4099  - http://www.jneurosci.org/content/32/1/62.short
4100  - http://www.jneurosci.org/content/32/1/62.full
SO  - J. Neurosci.2012 Jan 04; 32
AB  - GABAergic signaling in hippocampal pyramidal neurons undergoes a switch from depolarizing to hyperpolarizing during early neuronal development. Whether such a transformation of GABAergic action occurs in dentate granule cells (DGCs), located at the first stage of the hippocampal trisynaptic circuit, is unclear. Here, we use noninvasive extracellular recording to monitor the effect of synaptically released GABA on the DGC population. We find that GABAergic responses in adolescent and adult rat DGCs are still depolarizing from rest. Using a morphologically realistic DGC model, we show that GABAergic action, depending on its precise timing and location, can have either an excitatory or inhibitory role in signal processing in the dentate gyrus.