RT Journal Article
SR Electronic
T1 Tamalin Is a Critical Mediator of Electroconvulsive Shock-Induced Adult Neuroplasticity
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 2252
OP 2262
DO 10.1523/JNEUROSCI.5493-11.2012
VO 32
IS 7
A1 Yanpallewar, Sudhirkumar U.
A1 Barrick, Colleen A.
A1 Palko, Mary Ellen
A1 Fulgenzi, Gianluca
A1 Tessarollo, Lino
YR 2012
UL http://www.jneurosci.org/content/32/7/2252.abstract
AB The molecular mechanisms underlying the effects of electroconvulsive shock (ECS) therapy, a fast-acting and very effective antidepressant therapy, are poorly understood. Changes related to neuroplasticity, including enhanced adult hippocampal neurogenesis and neuronal arborization, are believed to play an important role in mediating the effects of ECS. Here we show a dynamic upregulation of the scaffold protein tamalin, selectively in the hippocampus of animals subjected to ECS. Interestingly, this gene upregulation is functionally significant because tamalin deletion in mice abrogated ECS-induced neurogenesis in the adult mouse hippocampus. Furthermore, loss of tamalin blunts mossy fiber sprouting and dendritic arborization caused by ECS. These data suggest an essential role for tamalin in ECS-induced adult neuroplasticity and provide new insight into the pathways that are involved in mediating ECS effects.