RT Journal Article
SR Electronic
T1 Dorsoventral Differences in Intrinsic Properties in Developing CA1 Pyramidal Cells
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 3736
OP 3747
DO 10.1523/JNEUROSCI.5870-11.2012
VO 32
IS 11
A1 Marcelin, Béatrice
A1 Liu, Zhiqiang
A1 Chen, Yuncai
A1 Lewis, Alan S.
A1 Becker, Albert
A1 McClelland, Shawn
A1 Chetkovich, Dane M.
A1 Migliore, Michele
A1 Baram, Tallie Z.
A1 Esclapez, Monique
A1 Bernard, Christophe
YR 2012
UL http://www.jneurosci.org/content/32/11/3736.abstract
AB The dorsoventral and developmental gradients of entorhinal layer II cell grid properties correlate with their resonance properties and with their hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel current characteristics. We investigated whether such correlation existed in rat hippocampal CA1 pyramidal cells, where place fields also show spatial and temporal gradients. Resonance was absent during the first postnatal week, and emerged during the second week. Resonance was stronger in dorsal than ventral cells, in accord with HCN current properties. Resonance responded to cAMP in ventral but not in dorsal cells. The dorsoventral distribution of HCN1 and HCN2 subunits and of the auxiliary protein tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) could account for these differences between dorsal and ventral cells. The analogous distribution of the intrinsic properties of entorhinal stellate and hippocampal cells suggests the existence of general rules of organization among structures that process complementary features of the environment.