PT  - JOURNAL ARTICLE
AU  - Arroyo, Sergio
AU  - Bennett, Corbett
AU  - Aziz, David
AU  - Brown, Solange P.
AU  - Hestrin, Shaul
TI  - Prolonged Disynaptic Inhibition in the Cortex Mediated by Slow, Non-α7 Nicotinic Excitation of a Specific Subset of Cortical Interneurons
AID  - 10.1523/JNEUROSCI.0115-12.2012
DP  - 2012 Mar 14
TA  - The Journal of Neuroscience
PG  - 3859--3864
VI  - 32
IP  - 11
4099  - http://www.jneurosci.org/content/32/11/3859.short
4100  - http://www.jneurosci.org/content/32/11/3859.full
SO  - J. Neurosci.2012 Mar 14; 32
AB  - Cholinergic activation of nicotinic receptors in the cortex plays a critical role in arousal, attention, and learning. Here we demonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cortical interneurons via a remarkably slow, non-α7 nicotinic receptor-mediated conductance. In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits.