RT Journal Article
SR Electronic
T1 Prolonged Disynaptic Inhibition in the Cortex Mediated by Slow, Non-α7 Nicotinic Excitation of a Specific Subset of Cortical Interneurons
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 3859
OP 3864
DO 10.1523/JNEUROSCI.0115-12.2012
VO 32
IS 11
A1 Arroyo, Sergio
A1 Bennett, Corbett
A1 Aziz, David
A1 Brown, Solange P.
A1 Hestrin, Shaul
YR 2012
UL http://www.jneurosci.org/content/32/11/3859.abstract
AB Cholinergic activation of nicotinic receptors in the cortex plays a critical role in arousal, attention, and learning. Here we demonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cortical interneurons via a remarkably slow, non-α7 nicotinic receptor-mediated conductance. In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits.