RT Journal Article SR Electronic T1 Serotonin Selectively Modulates Reward Value in Human Decision-Making JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 5833 OP 5842 DO 10.1523/JNEUROSCI.0053-12.2012 VO 32 IS 17 A1 Seymour, Ben A1 Daw, Nathaniel D. A1 Roiser, Jonathan P. A1 Dayan, Peter A1 Dolan, Ray YR 2012 UL http://www.jneurosci.org/content/32/17/5833.abstract AB Establishing a function for the neuromodulator serotonin in human decision-making has proved remarkably difficult because if its complex role in reward and punishment processing. In a novel choice task where actions led concurrently and independently to the stochastic delivery of both money and pain, we studied the impact of decreased brain serotonin induced by acute dietary tryptophan depletion. Depletion selectively impaired both behavioral and neural representations of reward outcome value, and hence the effective exchange rate by which rewards and punishments were compared. This effect was computationally and anatomically distinct from a separate effect on increasing outcome-independent choice perseveration. Our results provide evidence for a surprising role for serotonin in reward processing, while illustrating its complex and multifarious effects.