RT Journal Article
SR Electronic
T1 Brain State Dependent Postinhibitory Rebound in Entorhinal Cortex Interneurons
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 6501
OP 6510
DO 10.1523/JNEUROSCI.5871-11.2012
VO 32
IS 19
A1 Adhikari, Mohit H.
A1 Quilichini, Pascale P.
A1 Roy, Dipanjan
A1 Jirsa, Viktor
A1 Bernard, Christophe
YR 2012
UL http://www.jneurosci.org/content/32/19/6501.abstract
AB Postinhibitory rebound (PIR) is believed to play an important role in the genesis and maintenance of biological rhythms. While it has been demonstrated during several in vitro studies, in vivo evidence for PIR remains scarce. Here, we report that PIR can be observed in the dorsomedial entorhinal cortex of anesthetized rats, mostly between putatively connected GABAergic interneurons, and that it is more prevalent during the theta (4–6 Hz) oscillation state than the slow (0.5–2 Hz) oscillation state. Functional inhibition was also found to be brain state and postsynaptic cell type dependent but that alone could not explain this brain state dependence of PIR. A theoretical analysis, using two Fitzhugh–Nagumo neurons coupled to an external periodic drive, predicted that the modulation of a faster spiking rate by the slower periodic drive could account for the brain state dependence of PIR. Model predictions were verified experimentally. We conclude that PIR is cell type and brain state dependent and propose that this could impact network synchrony and rhythmogenesis.