PT  - JOURNAL ARTICLE
AU  - Michael W. Cole
AU  - Tal Yarkoni
AU  - Grega Repovš
AU  - Alan Anticevic
AU  - Todd S. Braver
TI  - Global Connectivity of Prefrontal Cortex Predicts Cognitive Control and Intelligence
AID  - 10.1523/JNEUROSCI.0536-12.2012
DP  - 2012 Jun 27
TA  - The Journal of Neuroscience
PG  - 8988--8999
VI  - 32
IP  - 26
4099  - http://www.jneurosci.org/content/32/26/8988.short
4100  - http://www.jneurosci.org/content/32/26/8988.full
SO  - J. Neurosci.2012 Jun 27; 32
AB  - Control of thought and behavior is fundamental to human intelligence. Evidence suggests a frontoparietal brain network implements such cognitive control across diverse contexts. We identify a mechanism—global connectivity—by which components of this network might coordinate control of other networks. A lateral prefrontal cortex (LPFC) region's activity was found to predict performance in a high control demand working memory task and also to exhibit high global connectivity. Critically, global connectivity in this LPFC region, involving connections both within and outside the frontoparietal network, showed a highly selective relationship with individual differences in fluid intelligence. These findings suggest LPFC is a global hub with a brainwide influence that facilitates the ability to implement control processes central to human intelligence.