PT - JOURNAL ARTICLE AU - Massi, Lema AU - Lagler, Michael AU - Hartwich, Katja AU - Borhegyi, Zsolt AU - Somogyi, Peter AU - Klausberger, Thomas TI - Temporal Dynamics of Parvalbumin-Expressing Axo-axonic and Basket Cells in the Rat Medial Prefrontal Cortex <em>In Vivo</em> AID - 10.1523/JNEUROSCI.3475-12.2012 DP - 2012 Nov 14 TA - The Journal of Neuroscience PG - 16496--16502 VI - 32 IP - 46 4099 - http://www.jneurosci.org/content/32/46/16496.short 4100 - http://www.jneurosci.org/content/32/46/16496.full SO - J. Neurosci.2012 Nov 14; 32 AB - Axo-axonic interneurons, innervating exclusively axon initial segments, and parvalbumin-expressing basket interneurons, targeting somata, dendrites, and spines of pyramidal cells, have been proposed to control neuronal activity in prefrontal circuits. We recorded the spike-timing of identified neurons in the prelimbic cortex of anesthetized rats, and show that axo-axonic cells increase their firing during tail pinch-induced brain state-activation. In addition, axo-axonic cells differ from other GABAergic parvalbumin-expressing cells in their spike timing during DOWN- to UP-state transitions of slow oscillations and in their coupling to gamma and spindle oscillations. The distinct firing dynamics and synaptic targets of axo-axonic and other parvalbumin-expressing cells provide differential contributions to the temporal organization of prefrontal networks.