PT  - JOURNAL ARTICLE
AU  - Massi, Lema
AU  - Lagler, Michael
AU  - Hartwich, Katja
AU  - Borhegyi, Zsolt
AU  - Somogyi, Peter
AU  - Klausberger, Thomas
TI  - Temporal Dynamics of Parvalbumin-Expressing Axo-axonic and Basket Cells in the Rat Medial Prefrontal Cortex <em>In Vivo</em>
AID  - 10.1523/JNEUROSCI.3475-12.2012
DP  - 2012 Nov 14
TA  - The Journal of Neuroscience
PG  - 16496--16502
VI  - 32
IP  - 46
4099  - http://www.jneurosci.org/content/32/46/16496.short
4100  - http://www.jneurosci.org/content/32/46/16496.full
SO  - J. Neurosci.2012 Nov 14; 32
AB  - Axo-axonic interneurons, innervating exclusively axon initial segments, and parvalbumin-expressing basket interneurons, targeting somata, dendrites, and spines of pyramidal cells, have been proposed to control neuronal activity in prefrontal circuits. We recorded the spike-timing of identified neurons in the prelimbic cortex of anesthetized rats, and show that axo-axonic cells increase their firing during tail pinch-induced brain state-activation. In addition, axo-axonic cells differ from other GABAergic parvalbumin-expressing cells in their spike timing during DOWN- to UP-state transitions of slow oscillations and in their coupling to gamma and spindle oscillations. The distinct firing dynamics and synaptic targets of axo-axonic and other parvalbumin-expressing cells provide differential contributions to the temporal organization of prefrontal networks.