RT Journal Article SR Electronic T1 Temporal Dynamics of Parvalbumin-Expressing Axo-axonic and Basket Cells in the Rat Medial Prefrontal Cortex In Vivo JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 16496 OP 16502 DO 10.1523/JNEUROSCI.3475-12.2012 VO 32 IS 46 A1 Massi, Lema A1 Lagler, Michael A1 Hartwich, Katja A1 Borhegyi, Zsolt A1 Somogyi, Peter A1 Klausberger, Thomas YR 2012 UL http://www.jneurosci.org/content/32/46/16496.abstract AB Axo-axonic interneurons, innervating exclusively axon initial segments, and parvalbumin-expressing basket interneurons, targeting somata, dendrites, and spines of pyramidal cells, have been proposed to control neuronal activity in prefrontal circuits. We recorded the spike-timing of identified neurons in the prelimbic cortex of anesthetized rats, and show that axo-axonic cells increase their firing during tail pinch-induced brain state-activation. In addition, axo-axonic cells differ from other GABAergic parvalbumin-expressing cells in their spike timing during DOWN- to UP-state transitions of slow oscillations and in their coupling to gamma and spindle oscillations. The distinct firing dynamics and synaptic targets of axo-axonic and other parvalbumin-expressing cells provide differential contributions to the temporal organization of prefrontal networks.