RT Journal Article
SR Electronic
T1 Strength of Coupling within a Mnemonic Control Network Differentiates Those Who Can and Cannot Suppress Memory Retrieval
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 5017
OP 5026
DO 10.1523/JNEUROSCI.3459-12.2013
VO 33
IS 11
A1 Pedro M. Paz-Alonso
A1 Silvia A. Bunge
A1 Michael C. Anderson
A1 Simona Ghetti
YR 2013
UL http://www.jneurosci.org/content/33/11/5017.abstract
AB The ability to direct our thought processes influences not only what we do, but also what we remember later. Here we sought to identify the brain network that supports the ability to control memory retrieval and to understand the neural basis of age-related changes and individual differences in the capacity for mnemonic control. To this end, we collected functional MRI data from 43 children and young adults while they attempted to retrieve or suppress retrieval of previously learned associations. Seed-based functional connectivity analyses revealed a largely right-lateralized dorsolateral prefrontal cortex-cingulate-parietal-hippocampal network that exhibited strongly correlated activity during retrieval suppression. Regardless of age, individuals who were able to suppress memory retrieval exhibited tighter coupling between key nodes in this dorsolateral prefrontal cortex-cingulate-parietal-hippocampal network than individuals who did not. Further, only those capable of mnemonic control exhibited tighter coupling during successful retrieval suppression (intentional forgetting) than during unsuccessful retrieval (unintentional forgetting). Across both children and adults, individual differences in retrieval suppression were best explained by the strength of these network interactions.