RT Journal Article
SR Electronic
T1 Anatomical Segregation of Visual Selection Mechanisms in Human Parietal Cortex
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 6225
OP 6229
DO 10.1523/JNEUROSCI.4983-12.2013
VO 33
IS 14
A1 Capotosto, Paolo
A1 Tosoni, Annalisa
A1 Spadone, Sara
A1 Sestieri, Carlo
A1 Perrucci, Mauro Gianni
A1 Romani, Gian Luca
A1 Della Penna, Stefania
A1 Corbetta, Maurizio
YR 2013
UL http://www.jneurosci.org/content/33/14/6225.abstract
AB Visual selection requires mechanisms for representing object salience and for shifting the focus of processing to novel objects. It is not clear from computational or neural models whether these operations are performed within the same or different brain regions. Here, we use repetitive transcranial magnetic stimulation to briefly interfere with neural activity in individually localized regions of human posterior parietal cortex (PPC) that are putatively involved in attending to contralateral locations or shifting attention between locations. Stimulation over right ventral intraparietal sulcus impaired target discrimination at contralateral locations, whereas stimulation over right medial superior parietal lobule impaired target discrimination after a shift of attention regardless of its location. This double dissociation is consistent with neuroimaging studies and indicates that mechanisms of visual selection are partly anatomically segregated in human PPC.