PT  - JOURNAL ARTICLE
AU  - Yue Wang
AU  - Qing Dong
AU  - Xu-Feng Xu
AU  - Xuan Feng
AU  - Jian Xin
AU  - Dong-Dong Wang
AU  - Hui Yu
AU  - Tian Tian
AU  - Zhe-Yu Chen
TI  - Phosphorylation of Cofilin Regulates Extinction of Conditioned Aversive Memory via AMPAR Trafficking
AID  - 10.1523/JNEUROSCI.5107-12.2013
DP  - 2013 Apr 10
TA  - The Journal of Neuroscience
PG  - 6423--6433
VI  - 33
IP  - 15
4099  - http://www.jneurosci.org/content/33/15/6423.short
4100  - http://www.jneurosci.org/content/33/15/6423.full
SO  - J. Neurosci.2013 Apr 10; 33
AB  - Actin dynamics provide an important mechanism for the modification of synaptic plasticity, which is regulated by the actin depolymerizing factor (ADF)/cofilin. However, the role of cofilin regulated actin dynamics in memory extinction process is still unclear. Here, we observed that extinction of conditioned taste aversive (CTA) memory led to temporally enhanced ADF/cofilin activity in the infralimbic cortex (IrL) of the rats. Moreover, temporally elevating ADF/cofilin activity in the IrL could accelerate CTA memory extinction by facilitating AMPAR synaptic surface recruitment, whereas inhibition of ADF/cofilin activity abolished AMPAR synaptic surface trafficking and impaired memory extinction. Finally, we observed that ADF/cofilin-regulated synaptic plasticity was not directly coupled to morphological changes of postsynaptic spines. These findings may help us understand the role of ADF/cofilin-regulated actin dynamics in memory extinction and suggest that appropriate manipulating ADF/cofilin activity might be a suitable way for therapeutic treatment of memory disorders.