RT Journal Article
SR Electronic
T1 Midbrain-Derived Neurotrophins Support Survival of Immature Striatal Projection Neurons
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 3363
OP 3369
DO 10.1523/JNEUROSCI.3687-12.2013
VO 33
IS 8
A1 Baydyuk, Maryna
A1 Xie, Yuxiang
A1 Tessarollo, Lino
A1 Xu, Baoji
YR 2013
UL http://www.jneurosci.org/content/33/8/3363.abstract
AB Neuronal death occurs at several stages during embryogenesis and early postnatal development; however, it is unknown how the survival of immature neurons at their origin is regulated before these cells migrate to their final destination. Striatal projection neurons, known as medium-sized spiny neurons (MSNs), in both the direct and indirect pathways are generated in the lateral ganglionic eminence (LGE). Here we report that brain-derived neurotrophic factor and neurotrophin-3 are anterogradely transported from midbrain dopaminergic neurons and support the survival of immature MSNs of the indirect and direct pathways, respectively, in the developing mouse striatum and LGE. These results reveal a novel mode of neurotrophic action in the nervous system by linking neurotrophins to the survival of immature neurons at their origin, while also suggesting that innervating neurons may control the size of their targeting neuronal population in the brain.