RT Journal Article
SR Electronic
T1 GABA<sub>B</sub> Receptors Regulate Extrasynaptic GABA<sub>A</sub> Receptors
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 3780
OP 3785
DO 10.1523/JNEUROSCI.4989-12.2013
VO 33
IS 9
A1 William M. Connelly
A1 Sarah J. Fyson
A1 Adam C. Errington
A1 Cian P. McCafferty
A1 David W. Cope
A1 Giuseppe Di Giovanni
A1 Vincenzo Crunelli
YR 2013
UL http://www.jneurosci.org/content/33/9/3780.abstract
AB Tonic inhibitory GABAA receptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells, and cerebellar granule cells. Here we show that in rat brain slices, activation of postsynaptic GABAB receptors enhances the magnitude of the tonic GABAA current recorded in these cell types via a pathway involving Gi/o G proteins, adenylate cyclase, and cAMP-dependent protein kinase. Using a combination of pharmacology and knockout mice, we show that this pathway is independent of potassium channels or GABA transporters. Furthermore, the enhancement in tonic current is sufficient to significantly alter the excitability of thalamocortical neurons. These results demonstrate for the first time a postsynaptic crosstalk between GABAB and GABAA receptors.